This autumn, one of Italy’s most exclusive wellness destinations is inviting guests to rewire their minds and bodies from the inside out. From 27 October to 2 November 2025, Palazzo Fiuggi Wellness Medical Spa will host a six-day Mindset Biohacking Retreat led by high-performance coach Stefano Santori — a programme designed to unlock better health, sharper focus and lasting energy.
Santori, founder of the Mindset Biohacking protocol, has coached everyone from elite athletes to luxury brands like Ferrari. In Fiuggi, he will guide guests through a blend of medical science, behavioural transformation and immersive wellness rituals.
The experience begins with a comprehensive medical assessment — including ECG and biomechanical analysis — so that Santori and the medi-spa’s experts can create a personalised treatment plan. Over the week, guests will learn breathwork for nervous system regulation, nutrition optimisation, stress management techniques and strategies for achieving truly restorative sleep.
Cutting-edge therapies include:
Hypoxic-hyperoxic therapy for cellular health
Red and near-infrared light therapy for energy and recovery
Vagal nerve stimulation to reduce inflammation and improve sleep
Guests will also try the High Performance Method by biomechanical engineer and Olympic skeleton champion Stefano Maldifassi, targeting posture, mobility and functional strength. Daily mindfulness practices, circadian rhythm realignment and thermal spa rituals — from cold plunges to contrast therapy — round out the schedule. One highlight: a post-hike immersion in a nearby mountain river.
Nutrition is no afterthought. Palazzo Fiuggi’s three-Michelin-starred chef Heinz Beck has crafted an anti-inflammatory menu where science meets gastronomy. Dishes include marinated great amberjack with celery and oxidised chocolate, onion cream with turmeric and ginger, and scorpionfish with spring vegetables, all designed to reduce inflammation and boost antioxidants.
Rates start at €8,870 for six nights in a Charme Room suite (30–37 sq m), with all meals, therapies and protocols included.
“This retreat is a reset for one’s body and mind – the first step toward a longer, healthier life, lived with awareness and intention,” says Santori.
Palazzo Fiuggi’s Mindset Biohacking retreat promises the kind of holistic transformation that lingers long after checkout — where high performance isn’t just about doing more, but living better.
