Basic each way fares to both cities from £49 are available to book from today on www.ba.com
Flights to London City Airport in the heart of the capital will operate northbound on Fridays and southbound on Sundays, an ideal commute for business customers.
In May the airline launched seven new summer-only routes from Manchester to popular leisure destinations in Europe as well as London City, providing more than 35,000 extra seats from the North West.
British Airways also operates up to 10 return flights a day between Manchester and London Heathrow.
The new summer routes operate until October and the London City service will resume on December 15 along with flights to Salzburg and Chambery.